(25R)- and (25S)-25-hydroxy-27-nor-cholesterol 1c, were prepared by enzymatic resolution of the stereogenic center in the side chain of compound 4a or by synthesis of the side chain using, as a chiral synthon, the enantiomerically pure phenylsulfonyl alkanol 6a prepared by different biocatalytic approaches. (C) 1999 Elsevier Science Ltd. All rights reserved.

Chemoenzymatic syntheses of (25R)- and (25S)-25-hydroxy-27-nor-cholesterol, a steroid bearing a secondary hydroxy group in the side chain / P. Ferraboschi, F. Pecora, S. Reza-Elahi, E. Santaniello. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 10:13(1999), pp. 2497-2500. [10.1016/S0957-4166(99)00257-8]

Chemoenzymatic syntheses of (25R)- and (25S)-25-hydroxy-27-nor-cholesterol, a steroid bearing a secondary hydroxy group in the side chain

P. Ferraboschi
Primo
;
E. Santaniello
Ultimo
1999

Abstract

(25R)- and (25S)-25-hydroxy-27-nor-cholesterol 1c, were prepared by enzymatic resolution of the stereogenic center in the side chain of compound 4a or by synthesis of the side chain using, as a chiral synthon, the enantiomerically pure phenylsulfonyl alkanol 6a prepared by different biocatalytic approaches. (C) 1999 Elsevier Science Ltd. All rights reserved.
Settore BIO/10 - Biochimica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175677
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