The conformational space of the tetrasaccharide α-L-Fuc-(1 → 2)-β-D-Gal-(1 → 3)-β-D-GalNAc-(1 → 3)-α-D-Gal1Pr (3) and of some overlapping di- and trisaccharide sequences was investigated with the aid of molecular mechanics energy minimizations, molecular-dynamics simulations, and 1H-NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc-Gal and Gal-GalNAc) is combined with the flexibility of the third one (GalNAc-Gal).
Oligosaccharides Related to Tumor-Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di- and trisaccharide sequences / L. Toma, D. Colombo, F. Ronchetti, L. Panza, G. Russo. - In: HELVETICA CHIMICA ACTA. - ISSN 0018-019X. - 78:3(1995), pp. 636-646. [10.1002/hlca.19950780311]
Oligosaccharides Related to Tumor-Associate Antigens. Part 4. Modeling of the terminal tetrasaccharide of an antigen recognized by the MBr1 antibody and of overlapping Di- and trisaccharide sequences
D. ColomboSecondo
;F. Ronchetti;G. RussoUltimo
1995
Abstract
The conformational space of the tetrasaccharide α-L-Fuc-(1 → 2)-β-D-Gal-(1 → 3)-β-D-GalNAc-(1 → 3)-α-D-Gal1Pr (3) and of some overlapping di- and trisaccharide sequences was investigated with the aid of molecular mechanics energy minimizations, molecular-dynamics simulations, and 1H-NMR analysis. These investigations suggested that in compound 3 a certain rigidity of the first two glycosidic linkages (Fuc-Gal and Gal-GalNAc) is combined with the flexibility of the third one (GalNAc-Gal).
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