An improved gas-chromatographic procedure was developed and tested for evaluating plasmatic trichloroacetic acid (TCA), a terminal metabolite of trichloroethylene and tetrachloroethylene, pollutants widely diffused in the environment. It determines the chloroform produced by TCA thermal decarboxylation. The specificity, sample preservation, decarboxylation phase, qualitative and quantitative analysis of chloroform in the static head space have been discussed and documented. The sensitivity of the procedure (2 μg/L plasma) is adequate to the environmental exposure. Good accuracy and precision is possible.
A procedure for determining plasmatic trichloroacetic acid in human subjects exposed to chlorinated solvents at environmental levels / G. Ziglio, G. Beltramelli, F. Pregliasco. - In: ARCHIVES OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY. - ISSN 0090-4341. - 13:2(1984 Mar), pp. 129-134.
Titolo: | A procedure for determining plasmatic trichloroacetic acid in human subjects exposed to chlorinated solvents at environmental levels |
Autori: | PREGLIASCO, FABRIZIO ERNESTO (Ultimo) |
Parole Chiave: | Air Pollutants, Occupational ; Chromatography, Gas ; Humans ; Hydrocarbons, Chlorinated ; Solvents ; Trichloroacetic Acid |
Settore Scientifico Disciplinare: | Settore MED/42 - Igiene Generale e Applicata |
Data di pubblicazione: | mar-1984 |
Rivista: | |
Tipologia: | Article (author) |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/BF01055869 |
Appare nelle tipologie: | 01 - Articolo su periodico |