RATIONALE AND OBJECTIVES: Sex, age, or functional-asymmetry-related variations in the size and shape characteristics of the midsagittal magnetic resonance (MR) image of the human corpus callosum (CC) have been widely investigated in the last 10 years, with conflicting results. In the current study, the authors attempted to analyze the sex- and age-related shape differences of the human CC in a large sample of adult subjects from a mathematical standpoint. METHODS: On the midsagittal MR images of 143 neurologically intact adults (75 women, 68 men, 21 to 81 years of age) the outline of the CC was identified. The shape of the CC was quantified using elliptic Fourier analysis, which allows for a global evaluation of the shape of organs identified by their outlines independent of their size, spatial orientation, and relation to reference planes. Subjects were grouped by sex and age. RESULTS: The shape of the human CC within age and sex class was highly variable. The analysis of variance showed a significant effect of age; however no significant sex differences could be demonstrated. CONCLUSIONS: Larger sample sizes are required to definitively assess the normal shape variations in human CC. The method developed also could be applied to the comparison of healthy and diseased individuals.

Shape of the human corpus callosum: elliptic Fourier analysis on midsagittal magnetic resonance scans / V.F. Ferrario, C. Sforza, G. Serrao, T. Frattini, C. Del Favero. - In: INVESTIGATIVE RADIOLOGY. - ISSN 0020-9996. - 29:7(1994), pp. 677-681. [10.1097/00004424-199407000-00003]

Shape of the human corpus callosum: elliptic Fourier analysis on midsagittal magnetic resonance scans

V.F. Ferrario;C. Sforza;G. Serrao;
1994

Abstract

RATIONALE AND OBJECTIVES: Sex, age, or functional-asymmetry-related variations in the size and shape characteristics of the midsagittal magnetic resonance (MR) image of the human corpus callosum (CC) have been widely investigated in the last 10 years, with conflicting results. In the current study, the authors attempted to analyze the sex- and age-related shape differences of the human CC in a large sample of adult subjects from a mathematical standpoint. METHODS: On the midsagittal MR images of 143 neurologically intact adults (75 women, 68 men, 21 to 81 years of age) the outline of the CC was identified. The shape of the CC was quantified using elliptic Fourier analysis, which allows for a global evaluation of the shape of organs identified by their outlines independent of their size, spatial orientation, and relation to reference planes. Subjects were grouped by sex and age. RESULTS: The shape of the human CC within age and sex class was highly variable. The analysis of variance showed a significant effect of age; however no significant sex differences could be demonstrated. CONCLUSIONS: Larger sample sizes are required to definitively assess the normal shape variations in human CC. The method developed also could be applied to the comparison of healthy and diseased individuals.
Settore BIO/16 - Anatomia Umana
1994
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/175144
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