Morphine (200 micrograms/rat) was injected intraventricularly (i.v.t.) into normal and into long-term castrated (4 weeks) adult male rats. Animals were killed 10, 20, 40 and 60 min after treatment. In normal animals, the treatment with morphine resulted in a significant increase of serum prolactin concentrations at all time intervals considered. However, the i.v.t. injection of 200 micrograms morphine/rat into castrated rats did not exert any significant effect on prolactin release at any time interval considered. When morphine (200 micrograms/rat) was administered i.v.t. together with the specific opioid receptor blocker naloxone (7.5 or 15 micrograms/rat) the stimulatory effect of morphine on prolactin release was diminished at 10 min, and totally blocked at 20 min. Naloxone given alone did not influence serum prolactin concentrations. The results suggest that the presence of endogenous androgens is essential to permit the stimulatory effect of morphine on prolactin release.

Morphine stimulates prolactin release in normal but not in castrated male rats / P. Limonta, F. Piva, R. Maggi, D. Dondi, M. Motta, L. Martini. - In: JOURNAL OF REPRODUCTION AND FERTILITY. - ISSN 0022-4251. - 76:2(1986 Mar), pp. 745-750. [10.1530/jrf.0.0760745]

Morphine stimulates prolactin release in normal but not in castrated male rats

P. Limonta
Primo
;
F. Piva
Secondo
;
R. Maggi;D. Dondi;M. Motta
Penultimo
;
L. Martini
Ultimo
1986-03

Abstract

Morphine (200 micrograms/rat) was injected intraventricularly (i.v.t.) into normal and into long-term castrated (4 weeks) adult male rats. Animals were killed 10, 20, 40 and 60 min after treatment. In normal animals, the treatment with morphine resulted in a significant increase of serum prolactin concentrations at all time intervals considered. However, the i.v.t. injection of 200 micrograms morphine/rat into castrated rats did not exert any significant effect on prolactin release at any time interval considered. When morphine (200 micrograms/rat) was administered i.v.t. together with the specific opioid receptor blocker naloxone (7.5 or 15 micrograms/rat) the stimulatory effect of morphine on prolactin release was diminished at 10 min, and totally blocked at 20 min. Naloxone given alone did not influence serum prolactin concentrations. The results suggest that the presence of endogenous androgens is essential to permit the stimulatory effect of morphine on prolactin release.
Stimulation, Chemical ; Rats, Inbred Strains ; Rats ; Prolactin ; Morphine ; Animals ; Gonadal Steroid Hormones ; Male ; Orchiectomy ; Naloxone
Settore BIO/09 - Fisiologia
Settore BIO/13 - Biologia Applicata
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/175109
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