Natural cytotoxicity receptors (NCRs) were originally identified as specific natural killer cell activating receptors that, on binding to their endogenous ligands, trigger the killing of tumor cell targets. We recently described the differentiation of a novel subset of NCR+Vdelta1 T cells characterized by a remarkably high cytolytic potential against cancer cells. Here we demonstrate that the engagement of NKp30, one of the NCRs expressed de novo on Vdelta1 T cells after stimulation, triggers the production of high levels of CCL3/MIP-1alpha, CCL4/ MIP-1beta, and CCL5/RANTES but not of CXCL12/SDF-1. In turn, this NKp30- induced secretion of cc-chemokines is able to significantly suppress the replication of a CCR5 tropic strain of HIV-1 in CD4+/CCR5+ infected PM1 cell lines. This experimental evidence disclosing an unanticipated antiviral function of NCR+ Vdelta1 T cells opens new avenues for understanding the pathogenic role and for manipulating the function of T cells in HIV-1 infection.
Engagement of NKp30 on Vdelta1 T cells induces the production of CCL3, CCL4 and CCL5 and suppresses HIV-1 replication / K. Hudspeth, M. Fogli, D.V. Correia, J. Mikulak, A. Roberto, S. Della Bella, B. Silva-Santos, D. Mavilio. - In: BLOOD. - ISSN 0006-4971. - 119:17(2012), pp. 4013-4016.
|Titolo:||Engagement of NKp30 on Vdelta1 T cells induces the production of CCL3, CCL4 and CCL5 and suppresses HIV-1 replication|
|Parole Chiave:||cell differentiation; cells cultured; chemokine CCL3; chemokine CCL4; chemokine CCL5; chemokines; enzyme-linked immunosorbent assay; HIV infections; HIV-1; humans; natural cytotoxicity triggering receptor 3; receptors; antigen T-cell; gamma-delta; T-lymphocyte subsets; virus replication|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1182/blood-2011-11-390153|
|Appare nelle tipologie:||01 - Articolo su periodico|