The impact of anti-TNF therapy on systemic immune responses in patients has not been clearly defined. Here, we examined Th1/Th2/Th17 cytokine expression, activation and proliferation of peripheral T cells from patients with psoriasis and inflammatory bowel disease before and during anti-TNF therapy. In parallel, we calculated the correlation with the clinical response and we monitored cytokine expression in biopsies from inflamed tissues. We evidenced a dual role of TNF-blockade. In peripheral blood, it increased the expression of cytokines such as IL-17, IL-10, and IFN-γ, and enhanced the expression of activation markers and the proliferative response of CD4 T cells to TCR stimulation. By contrast, in biopsies from target tissues, TNF-blockade diminished the expression of Th17/Th1 cytokine and early inflammatory genes. Importantly, the enhanced T cell responses to TCR-stimulation did not impair the clinical response to the therapy and, in responder patients, occurred with the concomitant down-regulation of inflammatory genes in the target tissues.
Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues / F. Bosè, L. Raeli, C. Garutti, E. Frigerio, A. Cozzi, M. Crimi, F. Caprioli, R. Scavelli, G.F. Altomare, J. Geginat, S. Abrignani, E. Reali. - In: CLINICAL IMMUNOLOGY. - ISSN 1521-6616. - 139:2(2011), pp. 164-176.
|Titolo:||Dual role of anti-TNF therapy: enhancement of TCR-mediated T cell activation in peripheral blood and inhibition of inflammation in target tissues|
ABRIGNANI, SERGIO (Corresponding)
|Parole Chiave:||T cell responses; Cytokine; Immunotherapy; Psoriasis; Inflammatory bowel disease; TNF-blockade|
|Settore Scientifico Disciplinare:||Settore MED/35 - Malattie Cutanee e Veneree|
|Data di pubblicazione:||2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.clim.2011.01.015|
|Appare nelle tipologie:||01 - Articolo su periodico|