PURPOSE: Despite the recent innovations, complications of prostate biopsy can occur. The aim of this study was a prospective monitoring of major septic complications occurring after transrectal prostate biopsy, to describe their causing agents, to report the clinical course of these patients, and to give guidelines based on our personal experience. METHODS: This prospective study was carried out between January 2009 and September 2010. Complications were evaluated by telephone interviews. RESULTS: Between January 2009 and September 2010, 447 (96.5%) completed the telephone interview. Urosepsis occurred in ten patients (2.2%) and in three cases evolved into septic shock. Of these ten patients, nine had a positive blood culture, of whom eight for Escherichia coli and one for Aeromonas hydrophila, Aeromonas caviae, and Aeromonas sobria. In seven cases, the E. coli isolated were resistant to fluoroquinolone and six produced an extended spectrum beta-lactamase. Six E. coli were classified as multidrug-resistant organisms. Of the 10 patients, one died after the onset of multiorgan failure. For the other nine, the mean time spent in the hospital was 9 days (range, 6-15 days). CONCLUSIONS: Escherichia coli are developing new drug resistances. Early recognition of patients who harbor MDRO E. coli in their rectum or in the urine could be an important strategy for preventing sepsis. If a patient who has recently undergone transrectal prostate biopsy shows clinical signs of sepsis in the 48 h, a multiresistant E. coli infection must be suspected. The patient must be admitted urgently to the hospital, and carbapenem antibiotic therapy should be started.
Bacterial sepsis following prostatic biopsy / L.F. Carmignani, S.C.M. Picozzi, M.G. Spinelli, S. Di Pierro, G. Mombelli, E. Negri, M. Tejada, P. Gaia, E. Costa, A. Maggioni. - In: INTERNATIONAL UROLOGY AND NEPHROLOGY. - ISSN 0301-1623. - 44:4(2012 Aug), pp. 1055-1063.
|Titolo:||Bacterial sepsis following prostatic biopsy|
CARMIGNANI, LUCA FABIO (Primo)
PICOZZI, STEFANO CARLO MARIA (Secondo)
COSTA, ELENA (Penultimo)
MAGGIONI, AUGUSTO (Ultimo)
|Parole Chiave:||prostate biopsy ; sepsis ; fever ; prostate cancer|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||ago-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s11255-012-0145-9|
|Appare nelle tipologie:||01 - Articolo su periodico|