Negative pressure therapy potential enhancement with a biointeractive hyaluronan acid scaffold interface : case report

Negative pressure therapy (NPT) has been extensively applied to various difficult wounds, often achieving positive results. The therapy contributes to local edema reduction, stimulates cell proliferation, and enhances vascularity.1 The effectiveness in chronic wound care may be boosted if used in conjunction with a biological scaffold offering support to cells on the surface. Biological scaffolds could assist stabilization of the wound bed and improve receptivity for definitive skin grafting. We describe our recent experience in the adoption of a nonwoven esterified hyaluronan fiber scaffold used in tissue engineering as a substrate for cell culture (Hyalograft, Fab—Fidia Advanced Biopolymers, Abano Terme, Italy), whose characteristics could allow for a synergic effect if coupled with NPT.