Giant cell tumor of bone (GCTB) is a common primary neoplasm of bone characterized by distinctive clinicopathological features. GCTB is exceedingly rare in nonhuman species, and it has been sporadically reported in cats, dogs, rats, and birds. This report describes a primary murine bone tumor that shares striking clinicopathological similarities with human GCTB. The neoplasm occurred in a 71-week-old C57BL/6 mouse heterozygous for the specific Trp53 R172H point mutation. Grossly, the tumor presented as a mono-ostotic nodular mass arising from the distal metaphysis of the right femur. Microscopically, the affected bone was effaced by an osteolytic neoplasm with focal infiltrations into the surrounding tissues. Similarly to what was reported for human GCTB, the murine neoplasm consisted of 3 main cell populations: (1) bundles of pleomorphic spindle-shaped mononuclear cells displaying an indefinite mesenchymal histogenesis with immunohistochemical expression of vimentin and smooth muscle actin, (2) scattered multinucleated giant cells exhibiting osteoclast differentiation with prominent tartrate-resistant acid phosphatase activity and immunoreactivity for monocyte/macrophage markers including CD45 and lysozyme, and (3) scattered round mononuclear cells consistent with activated macrophages and expressing CD45, lysozyme, and F4/80. Based on these morphological and immunohistological results, the murine bone tumor described in this study has been putatively classified as GCTB.
Giant Cell Tumor of Bonelike Lesion in a Trp53 Mutant Mouse / E. Radaelli, A. Rustighi, E. Scanziani. - In: TOXICOLOGIC PATHOLOGY. - ISSN 0192-6233. - 40:4(2012 Jun), pp. 675-681.
|Titolo:||Giant Cell Tumor of Bonelike Lesion in a Trp53 Mutant Mouse|
RADAELLI, ENRICO (Primo)
SCANZIANI, EUGENIO (Ultimo)
|Parole Chiave:||mouse; multinucleated giant cell; osteoclast precursors; primary bone tumor; spindle-shaped mononuclear cells; Tpr53 mutation|
|Settore Scientifico Disciplinare:||Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria|
|Data di pubblicazione:||giu-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1177/0192623311436186|
|Appare nelle tipologie:||01 - Articolo su periodico|