Background: Between 40 and 50% of elderly people (>65 years old) are vaccinated against seasonal influenza in Italy every year. However active immunization only occurs in a relatively small number of vaccinated people and does not always last for the entire winter season. Oxidative stress might be one of the factors involved in this low antibody response. Aims: To assess whether supplementation with a compound based on resveratrol reduces oxidative stress and increases the proportion of immunized people. Design and methods: Seventy-one elderly subjects (>65 years old), 26 of which were affected with mild-moderate COPD, who voluntarily underwent vaccination for the 2009-2010 season, were randomly assigned to receive a supplement based on resveratrol (n=35) or no supplement (n=36) for four consecutive twenty-day cycles. The first cycle started five days before the vaccination. The antibody titre against one of the three antigens contained in the vaccine [A/Brisbane/10/2007 (H3N2)] was measured before the vaccination (T-5) and again after 20 days (T1) and 4 months (T2). Oxidative stress was also measured (plasma H2O2) at times T1 and T2. Respiratory episodes were recorded from the vaccination up to the end of the trial. Results: Active immunization, defined as an increase in antibody titre ≥4 times baseline, occurred in 45.4% of supplemented subjects and 27.3% of controls (p<0.05). Significant decreases were also observed in oxidative stress (-21.5%; p<0.05) and respiratory episodes (-11.5%; p=0,058) in the supplementation group compared to subjects who had only received vaccine. The decrease in oxidative stress was lower in the COPD subgroup than in the whole study population. Conclusions: Administering a compound based on resveratrol decreases oxidative stress and increases the number of immune subjects four months after vaccination.
|Titolo:||L'uso di sostanze antiossidanti ed immunomodulanti in una popolazione anziana sottoposta a vaccinazione antinfluenzale aumenta la risposta anticorpale e riduce gli episodi respiratori|
PREGLIASCO, FABRIZIO ERNESTO (Primo)
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||giu-2010|
|Appare nelle tipologie:||01 - Articolo su periodico|