Lactogenic transmission plays an important role in the biology of lentiviruses such as HIV and SIV or the small ruminant lentiviruses (SRLV). In thisworkwe analyzed the characteristics of viruses that goats, naturally infected with two strains of SRLV, transmitted to their kids. The spectrumof viral genotypes transmitted was broader and the efficiency of transmission greater compared to their human and simian counterparts. The newly described A10 subgroup of SRLVwas more efficiently transmitted than the B1 genotype. The analysis of a particular stretch of the envelope glycoprotein encompassing a potential neutralizing epitope revealed that, as in SIV, the transmitted viruses were positively charged in this region, but, in contrast to SIV, they tended to lack a glycosylation site that might protect against antibody neutralization. We conclude that the physiology of the ruminant neonatal intestine, which permits the adsorption of infected maternal cells, shaped the evolution of these particular lentiviruses that represent a valid model of lactogenic lentivirus transmission.
Genetic analysis of small ruminant lentiviruses following lactogenic transmission / G. Pisoni, G. Bertoni, G. Manarolla, H.R. Vogt, L.M. Scaccabarozzi, C. Locatelli, P. Moroni. - In: VIROLOGY. - ISSN 0042-6822. - 407:1(2010), pp. 91-99.
|Titolo:||Genetic analysis of small ruminant lentiviruses following lactogenic transmission|
|Parole Chiave:||Goat ; Small ruminant lentivirus ; Colostrum ; Milk ; Transmission ; Lactogenic transmission ; Genotype ; Lentivirus ; Caprine arthritis encephalitis virus ; Maedi–Visna virus|
|Settore Scientifico Disciplinare:||Settore VET/05 - Malattie Infettive degli Animali Domestici|
|Data di pubblicazione:||2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.virol.2010.08.004|
|Appare nelle tipologie:||01 - Articolo su periodico|