Vasospasm of arterial conduits used for coronary surgical procedures is an important cause of postoperative graft failure. Mounting experimental evidence suggests that estrogen reverses acetylcholine-induced vasospasm of the coronary arteries in animals and humans. Estrogen also affects endothelium-derived constrictor factors. We therefore investigated the in vivo vasomotor responses to transdermal 17beta-estradiol of the left internal mammary artery (LIMA) grafted on the anterior descending coronary artery.

Acute effects of 17beta-estradiol on left internal mammary graft after coronary artery bypass grafting / G. Polvani, M.R. Marino, M. Roberto, L. Dainese, A. Parolari, G. Pompilio, S. Di Matteo, A. Fumero, A. Cannata, F. Barili, P. Biglioli. - In: ANNALS OF THORACIC SURGERY. - ISSN 0003-4975. - 74:3(2002 Sep), pp. 695-699. [10.1016/S0003-4975(02)03742-6]

Acute effects of 17beta-estradiol on left internal mammary graft after coronary artery bypass grafting

G. Polvani;A. Parolari;G. Pompilio;P. Biglioli
2002-09

Abstract

Vasospasm of arterial conduits used for coronary surgical procedures is an important cause of postoperative graft failure. Mounting experimental evidence suggests that estrogen reverses acetylcholine-induced vasospasm of the coronary arteries in animals and humans. Estrogen also affects endothelium-derived constrictor factors. We therefore investigated the in vivo vasomotor responses to transdermal 17beta-estradiol of the left internal mammary artery (LIMA) grafted on the anterior descending coronary artery.
Administration, Cutaneous ; Echocardiography, Doppler, Color; Postoperative Complications ; Vasodilation ; Humans ; Coronary Artery Bypass ; Coronary Vasospasm ; Aged ; Middle Aged ; Myocardial Revascularization ; Female ; Estradiol
Settore MED/23 - Chirurgia Cardiaca
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/170775
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