The efficacy of probiotics is currently well documented with regard to the improvement of gastrointestinal functions, whereas their potential role in the prevention of infectious respiratory diseases has not been sufficiently analyzed. PURPOSE OF THE STUDY AND METHODS: A 3-stage prospective, randomized, double blind, placebo-controlled study was carried out with several synbiotic preparations containing 3 to 5 strains of Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium lactis, lactoferrin and prebiotics such as either FOS (short-chain fructooligosaccharides) or GOS (galactooligosaccharides). The study was performed over 3 different winter seasons between 2003 and 2007, and was aimed at assessing the ability of the different preparations to improve intestinal functions and to increase the body's defences against respiratory infections. In 2003/04 (stage 1; 237 healthy volunteers) an active formulation (A) containing 3 probiotic strains and FOS was used versus placebo; in 2005/06 (stage 2; 234 healthy volunteers) the same formulation versus a similar preparation enriched with lactoferrin (B), and versus placebo; in 2006/07 (stage 3; 250 healthy volunteers), 2 new synbiotic formulations each containing 5 probiotics and FOS (C) or GOS (D), respectively, versus placebo.
A new chance of preventing winter diseases by the administration of synbiotic formulations / F.E. Pregliasco, G. Anselmi, L. Fonte, F. Giussani, S. Schieppati, L. Soletti. - In: JOURNAL OF CLINICAL GASTROENTEROLOGY. - ISSN 0192-0790. - 42 Suppl 3 Pt 2:Suppl. 3 Pt. 2(2008 Sep), pp. S224-S234.
|Titolo:||A new chance of preventing winter diseases by the administration of synbiotic formulations|
PREGLIASCO, FABRIZIO ERNESTO (Primo)
ANSELMI, GIOVANNI (Secondo)
|Parole Chiave:||Double-Blind Method ; Humans ; Lactobacillus rhamnosus ; Bifidobacterium ; Probiotics ; Lactobacillus ; Respiratory Tract Infections ; Intestines ; Oligosaccharides ; Adult ; Seasons ; Treatment Outcome ; Incidence ; Middle Aged|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
|Data di pubblicazione:||set-2008|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1097/MCG.0b013e31817e1c91|
|Appare nelle tipologie:||01 - Articolo su periodico|