Sex hormones modulate proliferation, apoptosis, migration, metastasis and angiogenesis in cancer cells influencing tumourigenesis from the early hyperplastic growth till the end-stage metastasis. Although decades of studies have detailed these effects at the level of molecular pathways, where and when these actions are needed for the growth and progression of hormone-dependent neoplasia is poorly elucidated. Investigation of the hormone influences in carcinogenesis in the spatio-temporal dimension is expected to unravel critical steps in tumour progression and in the onset of resistance to hormone therapies. Non-invasive in vivo imaging represents a powerful tool to follow in time hormone signalling in the whole body during tumour development. This review summarizes the tools currently available to follow hormone action in living organisms.

Novel insights on imaging sex-hormone-dependent tumourigenesis in vivo / B. Ramachandran, A. Stell, L. Maravigna, A. Maggi, P. Ciana. - In: ENDOCRINE-RELATED CANCER. - ISSN 1351-0088. - 18:3(2011 Apr), pp. R41-R51.

Novel insights on imaging sex-hormone-dependent tumourigenesis in vivo

B. Ramachandran
Primo
;
A. Stell
Secondo
;
L. Maravigna;A. Maggi
Penultimo
;
P. Ciana
Ultimo
2011-04

Abstract

Sex hormones modulate proliferation, apoptosis, migration, metastasis and angiogenesis in cancer cells influencing tumourigenesis from the early hyperplastic growth till the end-stage metastasis. Although decades of studies have detailed these effects at the level of molecular pathways, where and when these actions are needed for the growth and progression of hormone-dependent neoplasia is poorly elucidated. Investigation of the hormone influences in carcinogenesis in the spatio-temporal dimension is expected to unravel critical steps in tumour progression and in the onset of resistance to hormone therapies. Non-invasive in vivo imaging represents a powerful tool to follow in time hormone signalling in the whole body during tumour development. This review summarizes the tools currently available to follow hormone action in living organisms.
Settore BIO/14 - Farmacologia
Settore BIO/18 - Genetica
Article (author)
File in questo prodotto:
File Dimensione Formato  
Ramachandran ERC 2011.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 204.74 kB
Formato Adobe PDF
204.74 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/170426
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 5
  • ???jsp.display-item.citation.isi??? 9
social impact