This prospective study describes valvular abnormalities assessed by transesophageal echocardiography (TEE) in patients with primary antiphospholipid syndrome (APLS) over a 5-year follow-up. Of the 56 patients with APLS evaluated at baseline, 47 (84%) had repeat TEE examinations, including 3 patients who died before the end of the follow-up. The first TEE study showed cardiac involvement (thickening or vegetations and embolic sources) in 34 subjects (61%), with mitral valve thickening, the most common abnormality, present in 30 patients (54%). Embolic sources were found in 14 patients (25%; 9 severe spontaneous echocardiographic contrast, 5 Libman-Sacks endocarditis), associated with mitral valve thickening or stenosis in 10 patients. Over the 5-year follow-up, cardiac involvement was unchanged in 30 subjects (64%). New cardiac abnormalities were observed in 17 patients (36%), 15 (88%) with high immunoglobulin-G (IgG) anticardiolipin antibody (aCL) titers and 2 (12%) with low IgG aCL titers. In conclusion, this study showed that mitral valve thickening and embolic sources are frequently observed in patients with APLS. Anticoagulant and/or antiplatelet treatment was ineffective in terms of valvular lesion regression. New appearances of cardiac involvement are significantly related to high IgG aCL titers. (copyright) 2005 Elsevier Inc. All rights reserved.
|Titolo:||Five-year follow-up by transesophageal echocardiographic studies in primary antiphospholipid syndrome|
|Autori interni:||TURIEL, MAURIZIO (Primo)|
|Parole Chiave:||adult ; aged ; antibody titer ; antiphospholipid syndrome ; article ; contrast echocardiography ; embolism ; endocarditis ; female ; follow up ; heart valve ; human ; major clinical study ; male ; mitral valve stenosis ; mitral valve ; priority journal ; thrombosis ; transesophageal echocardiography ; acenocoumarol ; acetylsalicylic acid ; anticoagulant agent ; antithrombocytic agent ; cardiolipin antibody ; immunoglobulin G antibody ; steroid|
|Settore Scientifico Disciplinare:||Settore MED/09 - Medicina Interna|
|Data di pubblicazione:||2005|
|Digital Object Identifier (DOI):||10.1016/j.amjcard.2005.04.022|
|Appare nelle tipologie:||01 - Articolo su periodico|