The effect of Mangifera indica L. extract (Vimang®) on treatment of injury associated with hepatic ischaemia/reperfusion was tested. Vimang® protects from the oxidative damage induced by oxygen-based free radicals as shown in several in vitro test systems conducted. The ability of Vimang® to reduce liver damage was investigated in rats undergoing right-lobe blood flow occlusion for 45 min followed by 45 min of reperfusion. The ischaemia/reperfusion model leads to an increase of transaminase (ALT and AST), membrane lipid peroxidation, tissue neutrophil infiltration, DNA fragmentation, loss of protein -SH groups, cytosolic Ca2+ overload and a decrease of catalase activity. Oral administration of Vimang® (50, 110 and 250 mg/kg, b.w.) 7 days before reperfusion, reduced transaminase levels and DNA fragmentation in a dose dependent manner (p < 0.05). Vimang® also restored the cytosolic Ca2+ levels and inhibited polymorphonuclear migration at a dose of 250 mg/kg b.w., improved the oxidation of total and non protein sulfhydryl groups and prevented modification in catalase activity, uric acid and lipid peroxidation markers (p < 0.05). These data suggest that Vimang® could be a useful new natural drug for preventing oxidative damage during hepatic injury associated with free radical generation. Copyright

Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion / G.M. Sanchez, H.M.A. Rodriguez, A. Giuliani, A.J. Nunez Selles, N.P. Rodriguez, O.S. Leon Fernandez, L. Re. - In: PHYTOTHERAPY RESEARCH. - ISSN 0951-418X. - 17:3(2003), pp. 197-201.

Protective effect of Mangifera indica L. extract (Vimang) on the injury associated with hepatic ischaemia reperfusion

A. Giuliani;
2003

Abstract

The effect of Mangifera indica L. extract (Vimang®) on treatment of injury associated with hepatic ischaemia/reperfusion was tested. Vimang® protects from the oxidative damage induced by oxygen-based free radicals as shown in several in vitro test systems conducted. The ability of Vimang® to reduce liver damage was investigated in rats undergoing right-lobe blood flow occlusion for 45 min followed by 45 min of reperfusion. The ischaemia/reperfusion model leads to an increase of transaminase (ALT and AST), membrane lipid peroxidation, tissue neutrophil infiltration, DNA fragmentation, loss of protein -SH groups, cytosolic Ca2+ overload and a decrease of catalase activity. Oral administration of Vimang® (50, 110 and 250 mg/kg, b.w.) 7 days before reperfusion, reduced transaminase levels and DNA fragmentation in a dose dependent manner (p < 0.05). Vimang® also restored the cytosolic Ca2+ levels and inhibited polymorphonuclear migration at a dose of 250 mg/kg b.w., improved the oxidation of total and non protein sulfhydryl groups and prevented modification in catalase activity, uric acid and lipid peroxidation markers (p < 0.05). These data suggest that Vimang® could be a useful new natural drug for preventing oxidative damage during hepatic injury associated with free radical generation. Copyright
ischemia/reperfusion, antioxidant
Settore BIO/10 - Biochimica
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/17012
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