We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.

Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells / S. Casati, R. Ottria, E. Baldoli, E. Lopez, J.A. Maier, P. Ciuffreda. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 31:10(2011 Oct), pp. 3401-3406.

Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells

S. Casati
Primo
;
R. Ottria
Secondo
;
E. Baldoli;J.A. Maier
Penultimo
;
P. Ciuffreda
Ultimo
2011-10

Abstract

We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.
Drug Screening Assays, Antitumor ; Cytokinins ; Humans ; Cell Line, Tumor ; Drug Resistance, Neoplasm ; Cell Survival ; Isopentenyladenosine ; Neoplasms ; Cisplatin ; Neutral Red ; Ribonucleosides ; Adenosine ; Tumor Stem Cell Assay ; Zeatin
Settore BIO/10 - Biochimica
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/170096
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