We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.
Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells / S. Casati, R. Ottria, E. Baldoli, E. Lopez, J.A. Maier, P. Ciuffreda. - In: ANTICANCER RESEARCH. - ISSN 0250-7005. - 31:10(2011 Oct), pp. 3401-3406.
Effects of cytokinins, cytokinin ribosides and their analogs on the viability of normal and neoplastic human cells
S. CasatiPrimo
;R. OttriaSecondo
;E. Baldoli;J.A. MaierPenultimo
;P. CiuffredaUltimo
2011
Abstract
We examined the effects of some cytokinins and cytokinin ribosides including a series of adenosine analogs differently substituted in the N(6) position, along with some hypoxanthine derivatives on the viability of normal and neoplastic human cells. Cytokinins such as trans-zeatin, isopentenyladenine and benzyladenine do not show any effect, while cytokinin ribosides such as trans-zeatin riboside, isopentenyladenosine, and benzylaminopurine riboside impair the viability of normal and neoplastic cells, apart from colon carcinoma LoVo cells.File | Dimensione | Formato | |
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