The pineal hormone melatonin has been shown to exert a direct oncostatic activity on neoplastic cells, particularly from breast cancer. In the present study, we evaluated the effects of melatonin on the proliferation and on the cell cycle distribution of human androgen-independent DU 145 prostate cancer cells. Experiments were also performed to gain insights into the possible mechanism of action of the hormone.
Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells / M. Montagnani Marelli, P. Limonta, R. Maggi, M. Motta, R.M. Moretti. - In: THE PROSTATE. - ISSN 0270-4137. - 45:3(2000 Nov 01), pp. 238-244. [10.1002/1097-0045(20001101)45:3<238::AID-PROS6>3.0.CO;2-W]
Growth-inhibitory activity of melatonin on human androgen-independent DU 145 prostate cancer cells
M. Montagnani MarelliPrimo
;P. LimontaSecondo
;R. Maggi;R.M. MorettiUltimo
2000
Abstract
The pineal hormone melatonin has been shown to exert a direct oncostatic activity on neoplastic cells, particularly from breast cancer. In the present study, we evaluated the effects of melatonin on the proliferation and on the cell cycle distribution of human androgen-independent DU 145 prostate cancer cells. Experiments were also performed to gain insights into the possible mechanism of action of the hormone.
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