In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the "accelerator hypothesis" and could partially explain the rising frequency of T1D and T2D.

The potential role of glutamate in the current diabetes epidemic / A.M. Davalli, C. Perego, F.B. Folli. - In: ACTA DIABETOLOGICA. - ISSN 0940-5429. - 49:3(2012 Jan 05), pp. 167-183.

The potential role of glutamate in the current diabetes epidemic

A.M. Davalli
Primo
;
C. Perego
Secondo
;
2012-01-05

Abstract

In the present article, we propose the perspective that abnormal glutamate homeostasis might contribute to diabetes pathogenesis. Previous reports and our recent data indicate that chronically high extracellular glutamate levels exert direct and indirect effects that might participate in the progressive loss of β-cells occurring in both T1D and T2D. In addition, abnormal glutamate homeostasis may impact all the three accelerators of the "accelerator hypothesis" and could partially explain the rising frequency of T1D and T2D.
Diabetes; Glutamate toxicity; l-Glutamic acid; Monosodium glutamate; Obesity; Pancreatic β-cells
Settore BIO/09 - Fisiologia
Settore MED/13 - Endocrinologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/169646
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