Bovine viral diarrhea virus (BVDV) is a widespread and economically important pathogen of cattle; genetic typing of BVDV isolates distinguished two species, namely BVDV-1 and BVDV-2. BVDV-1 is the most widespread worldwide and it includes at least 11 subtypes. With the aim of clarifying the routes of circulation of BVDV-1 subtypes in an endemic area and in order to investigate the relationships between the genetic diversity of BVDV and its geographic distribution, a phylogenetic analysis of 5' untranslated region of Italian sequences was performed using a new Bayesian framework allowing the spatial-temporal reconstruction of the evolutionary dynamics of highly variable viruses. Our analyses suggested that different BVDV subtypes entered the North-Eastern part of Italy at different times within a time span between 23 and 7years ago. The largest virus dispersion occurred between the mid 1990s and the early 2000s. A possible gravity-like dynamic of the infection, originating in larger animal population then following patterns of national commercial-flow, should be hypothesized.
Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy / C. Luzzago, E. Ebranati, D. Sassera, A. Lo Presti, S. Lauzi, E. Gabanelli, M. Ciccozzi, G. Zehender. - In: INFECTION GENETICS AND EVOLUTION. - ISSN 1567-1348. - 12:2(2012 Mar), pp. 324-331.
Titolo: | Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy |
Autori: | LUZZAGO, CAMILLA (Primo) EBRANATI, ERIKA (Secondo) ZEHENDER, GIANGUGLIELMO (Ultimo) |
Parole Chiave: | RNA virus; Pestivirus; BVDV genotype 1; Phylogeography; Bayesian methods; Epidemiology |
Settore Scientifico Disciplinare: | Settore VET/05 - Malattie Infettive degli Animali Domestici Settore MED/42 - Igiene Generale e Applicata |
Data di pubblicazione: | mar-2012 |
Rivista: | |
Tipologia: | Article (author) |
Data ahead of print / Data di stampa: | 21-dic-2011 |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1016/j.meegid.2011.12.007 |
Appare nelle tipologie: | 01 - Articolo su periodico |
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