Bovine viral diarrhea virus (BVDV) is a widespread and economically important pathogen of cattle; genetic typing of BVDV isolates distinguished two species, namely BVDV-1 and BVDV-2. BVDV-1 is the most widespread worldwide and it includes at least 11 subtypes. With the aim of clarifying the routes of circulation of BVDV-1 subtypes in an endemic area and in order to investigate the relationships between the genetic diversity of BVDV and its geographic distribution, a phylogenetic analysis of 5' untranslated region of Italian sequences was performed using a new Bayesian framework allowing the spatial-temporal reconstruction of the evolutionary dynamics of highly variable viruses. Our analyses suggested that different BVDV subtypes entered the North-Eastern part of Italy at different times within a time span between 23 and 7years ago. The largest virus dispersion occurred between the mid 1990s and the early 2000s. A possible gravity-like dynamic of the infection, originating in larger animal population then following patterns of national commercial-flow, should be hypothesized.
Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy / C. Luzzago, E. Ebranati, D. Sassera, A. Lo Presti, S. Lauzi, E. Gabanelli, M. Ciccozzi, G. Zehender. - In: INFECTION GENETICS AND EVOLUTION. - ISSN 1567-1348. - 12:2(2012 Mar), pp. 324-331.
|Titolo:||Spatial and temporal reconstruction of bovine viral diarrhea virus genotype 1 dispersion in Italy|
LUZZAGO, CAMILLA (Primo)
EBRANATI, ERIKA (Secondo)
ZEHENDER, GIANGUGLIELMO (Ultimo)
|Parole Chiave:||RNA virus; Pestivirus; BVDV genotype 1; Phylogeography; Bayesian methods; Epidemiology|
|Settore Scientifico Disciplinare:||Settore VET/05 - Malattie Infettive degli Animali Domestici|
Settore MED/42 - Igiene Generale e Applicata
|Data di pubblicazione:||mar-2012|
|Data ahead of print / Data di stampa:||21-dic-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1016/j.meegid.2011.12.007|
|Appare nelle tipologie:||01 - Articolo su periodico|