Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC.
A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer / F. Bianchi, F. Nicassio, M. Marzi, E. Belloni, V. Dall'olio, L. Bernard, G. Pelosi, P. Maisonneuve, G. Veronesi, P.P. Di Fiore. - In: EMBO MOLECULAR MEDICINE. - ISSN 1757-4676. - 3:8(2011 Aug 03), pp. 495-503.
|Titolo:||A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer|
|Parole Chiave:||diagnosis; early stage; lung cancer; MiRNA; serum|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
|Data di pubblicazione:||3-ago-2011|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/emmm.201100154|
|Appare nelle tipologie:||01 - Articolo su periodico|
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