Background/Objective:The European Food Safety Authority (EFSA) recently published dietary guidelines for the intakes of carbohydrates, fiber, fats and water. We evaluated their role on the risk of a specific disease, known to be related to diet.Subjects/Methods:We used data from an Italian case-control study including 1953 colorectal cancer (CRC) cases and 4154 controls. We developed a so-called EFSA index summing up 1 point for adherence to each EFSA guideline. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) of CRC and its subsites were derived from unconditional multiple logistic regression models, for both the index and its components.Results:When each EFSA index component was analyzed separately, we found significant increased risks of CRC for non adherence to the guidelines on linoleic (OR=1.20, 95% CI, 1.07-1.36) and alpha-linolenic fatty acids (OR=1.19, 95% CI, 1.06-1.34). When all the guidelines were included in the same model, no significant association emerged. Compared with minimal adherence, the ORs of CRC for subsequent EFSA index scores were 1.03 (95% CI, 0.72-1.47), 1.05 (95% CI, 0.75-1.48), 1.04 (95% CI, 0.81-1.60), 0.99 (95% CI, 0.69-1.43), and 1.04 (95% CI, 0.67-1.61). No significant association emerged for colon and rectal cancer separately, and for males and females.Conclusions:Overall adherence to the EFSA dietary guidelines is not associated to colorectal, colon and rectal cancer risk in our population. Adherence to guidelines on linoleic and alpha-linolenic fatty acids may have a modest beneficial role on CRC risk.
Adherence to the European food safety authority's dietary recommendations and colorectal cancer risk / F. Turati, V. Edefonti, F. Bravi, M. Ferraroni, R. Talamini, A. Giacosa, M. Montella, M. Parpinel, C. La Vecchia, A. Decarli. - In: EUROPEAN JOURNAL OF CLINICAL NUTRITION. - ISSN 0954-3007. - 66:4(2012 Apr), pp. 517-522.
|Titolo:||Adherence to the European food safety authority's dietary recommendations and colorectal cancer risk|
TURATI, FEDERICA (Primo)
EDEFONTI, VALERIA CARLA (Secondo)
LA VECCHIA, CARLO VITANTONIO BATTISTA (Penultimo)
DECARLI, ADRIANO (Ultimo)
|Parole Chiave:||a priori dietary patterns; case control study; colorectal cancer; diet; guidelines adherence|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||apr-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1038/ejcn.2011.217|
|Appare nelle tipologie:||01 - Articolo su periodico|