Les altérations vasculaires rétiniennes des jeunes et les function hémostatique

Haemostatic function was studied in 40 patients between one and 12 months from the occurrence of retinal vein occlusion (RVO); 25 patients were aged 40 years or less and 15 were more than 45 years old. The following tests were performed: plasma β-thromboglobulin (β-TB) fibrinopeptide A (FpA), PTT, spontaneous in vitro platelet aggregation (SpA), circulating platelet aggregates (CPA), platelet retention (PR) to glass beads, serum thromboxane B2 (TxB2). In the group of older patients, there was a significant increase of β-TG, FpA, PR, SPA, TxB2, and a reduction in the PTT. CPA was not significantly changed. In the group of younger patients (< 40 yrs) only FpA and βTG levels showed significant differences from the control group of age-matched healthy subjects. These findings suggest that the alterations present in older patients are likely to be secondary to generalized vascular damage, whereas a state of activation of the coagulation system appears to be present in younger patients with RVO.