Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues, MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and stemness.

Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma / C. Casarsa, N.P. Bassani, F. Ambrogi, G. Zabucchi, P. Boracchi, E. Biganzoli, D. Coradini. - In: CANCER LETTERS. - ISSN 0304-3835. - 302:2(2011 Mar 28), pp. 136-143.

Epithelial-to-mesenchymal transition, cell polarity and stemness-associated features in malignant pleural mesothelioma

N.P. Bassani;F. Ambrogi;P. Boracchi;E. Biganzoli;
2011-03-28

Abstract

Epithelial-to-mesenchymal transition (EMT) is the fundamental process by which an epithelial cell loses its epithelial characteristics including cell polarity and acquires mesenchymal and stemness-related features. Therefore, we investigated whether malignant pleural mesothelioma (MPMs) histologies were associated with specific patterns of expression of a selected set of genes related to EMT, cell polarity and stemness features. The association between MPM histologies and genes expression were explored using active and passive Principal Components Analysis-based biplots and PAM analysis that provided evidence that with respect to normal tissues, MPMs histologies were better characterized by specific patterns of expression of genes involved in EMT activation, cell polarity and stemness.
malignant pleural mesothelioma; epithelial-to-mesenchymal transition; cell polarity; stemness features
Settore MED/01 - Statistica Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/167874
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