Experimental results and model calculations of excitation functions relevant to the production of specific radioisotopes for metabolic radiotherapy and for PET

First results are given from the comparison of experimental values and model calculations on accelerator-produced high specific activity radionuclides in no-carrier-added (NCA) form. The relevant radioisotopes are : Cu-64, produced by Zn-nat(d, alphaxn) and Zn-nat(d,2p) reactions, for simultaneous positron/negatron metabolic radiotherapy and PET imaging; Ga-66 high-energy positron emitter (4.2 MeV), produced by Zn-nat(d,xn) reactions, for metabolic radiotherapy and for PET: Re-186g, produced by W-186(p,n) and W-186(d,2n) reactions, for negatron (1.1 MeV) metabolic radiotherapy; At-211/Po-211, produced by Bi-209(alpha,2n) reaction (with spike of gamma emitter At-210 produced by Bi-209(alpha,3n) reaction) and Ac-225/Bi-213/Po-213 produced by Ra-226(p,2n) reaction, both for high-LET radiotherapy.