A simple and efficient method for synthesizing a range of hybrid nanocomposites based on a core of silica nanospheres (160, 330, and 660 nm in diameter) covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The magnetic and ultrasound characterization of the resulting nanocomposites shows that they have great potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging (MRI) and ultrasonography (US). The synthesis of a range of hybrid nanocomposites based on a core of silica covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The nanocomposites show potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging and ultrasonography. Copyright
Magnetic/Silica Nanocomposites as Dual-Mode Contrast Agents for Combined Magnetic Resonance Imaging and Ultrasonography / M.A. Malvindi, A. Greco, F. Conversano, A. Figuerola, M. Corti, M. Bonora ,A. Lascialfari, H. Amiri Doumari , M. Moscardini, R. Cingolani, G. Gigli, S. Casciaro, T. Pellegrino, A. Ragusa. - In: ADVANCED FUNCTIONAL MATERIALS. - ISSN 1616-301X. - 21:13(2011), pp. 2548-2555. [10.1002/adfm.201100031]
Magnetic/Silica Nanocomposites as Dual-Mode Contrast Agents for Combined Magnetic Resonance Imaging and Ultrasonography
A. Lascialfari;H. Amiri Doumari;
2011
Abstract
A simple and efficient method for synthesizing a range of hybrid nanocomposites based on a core of silica nanospheres (160, 330, and 660 nm in diameter) covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The magnetic and ultrasound characterization of the resulting nanocomposites shows that they have great potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging (MRI) and ultrasonography (US). The synthesis of a range of hybrid nanocomposites based on a core of silica covered by an outer shell of superparamagnetic nanoparticles, either iron oxide or heterodimeric FePt-iron oxide nanocrystals, is presented. The nanocomposites show potential as contrast agents for dual-mode imaging purposes, combining magnetic resonance imaging and ultrasonography. Copyright
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