Mesenchymal stromal cells may represent an ideal candidate to deliver anti-cancer drugs. In a previous study, we demonstrated that exposure of mouse bone marrow derived stromal cells to Doxorubicin led them to acquire anti-proliferative potential towards co-cultured haematopoietic stem cells (HSCs). We thus hypothesized whether freshly isolated human bone marrow Mesenchymal stem cells (hMSCs) and mature murine stromal cells (SR4987 line) primed in vitro with anti-cancer drugs and then localized near cancer cells, could inhibit proliferation.
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy / A. Pessina, A. Bonomi, V. Coccè, G. Invernici, S. Navone, L. Cavicchini, F. Sisto, M. Ferrari, L. Viganò, A. Locatelli, E. Ciusani, G. Cappelletti, D. Cartelli, C. Arnaldo, E. Parati, G. Marfia, R. Pallini, M.L. Falchetti, G. Alessandri. - In: PLOS ONE. - ISSN 1932-6203. - 6:12(2011 Dec), pp. e28321.e28321.1-e28321.e28321.11.
Mesenchymal Stromal Cells Primed with Paclitaxel Provide a New Approach for Cancer Therapy
A. Pessina;A. Bonomi;V. Coccè;L. Cavicchini;F. Sisto;G. Cappelletti;D. Cartelli;G. Marfia;
2011
Abstract
Mesenchymal stromal cells may represent an ideal candidate to deliver anti-cancer drugs. In a previous study, we demonstrated that exposure of mouse bone marrow derived stromal cells to Doxorubicin led them to acquire anti-proliferative potential towards co-cultured haematopoietic stem cells (HSCs). We thus hypothesized whether freshly isolated human bone marrow Mesenchymal stem cells (hMSCs) and mature murine stromal cells (SR4987 line) primed in vitro with anti-cancer drugs and then localized near cancer cells, could inhibit proliferation.
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