The reduction of the 2-keto acetals 1a and 1b by means of different microorganisms constitutes the biocatalytic access to optically active (46 to 100% ee) 2-hydroxy acetals, (S)-2a or (R)- and (S)-2b, representative compounds of a class of synthetically useful chiral building blocks.
Microbial reduction of 2-keto acetals as a biocatalytic approach to the enantioselective synthesis of optically active 2-hydroxy acetals / P. Ferraboschi, E. Santaniello, M. Tingoli, F. Aragozzini, F. Molinari. - In: TETRAHEDRON-ASYMMETRY. - ISSN 0957-4166. - 4:8(1993), pp. 1931-1940. [10.1016/S0957-4166(00)80434-6]
Microbial reduction of 2-keto acetals as a biocatalytic approach to the enantioselective synthesis of optically active 2-hydroxy acetals
P. FerraboschiPrimo
;E. SantanielloSecondo
;F. MolinariUltimo
1993
Abstract
The reduction of the 2-keto acetals 1a and 1b by means of different microorganisms constitutes the biocatalytic access to optically active (46 to 100% ee) 2-hydroxy acetals, (S)-2a or (R)- and (S)-2b, representative compounds of a class of synthetically useful chiral building blocks.
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