The greater part of the transition metals known as excellent catalysts for asymmetric synthesis has optically active diphosphine ligands as source of chirality; in spite of the great variety of chiral ligands available there is still demand for the development of catalysts which display the requirements of high enantioselectivity, diastereoselectivity and productivity in fine chemicals, fragrances, flavours, agrochemicals. Spurred by these observations we have developed some “mixed” electrondeficient aminophosphonite-phosphite and aminophosphonite-phosphinite. The term “mixed” indicates that the ligands gather one or more stereogenic sp3 carbon atoms of an alpha-aminoalcohol with the (R) or (S) atropisomeric chirality of the 1,1’-binaphthyl moiety. The Rh(I)-complexes derived from these chiral ligands can be valuable catalysts in hydroformylation of Carbapenem antibiotics precursors. Same selected results are summarized in the table.

Chiral Aminophosphonite-phosphite and Aminophosphonite-phosphinite Ligands in Asymmetric Hydroformylation of Carbapenem Antibiotics Precursors / S.R. Araneo, E. Cesarotti, I. Rimoldi, S. Tassi. ((Intervento presentato al 21. convegno Congresso Nazionale della Società Chimica Italiana tenutosi a Torino nel 2003.

Chiral Aminophosphonite-phosphite and Aminophosphonite-phosphinite Ligands in Asymmetric Hydroformylation of Carbapenem Antibiotics Precursors.

S.R. Araneo
Primo
;
E. Cesarotti
Secondo
;
I. Rimoldi
Penultimo
;
2003

Abstract

The greater part of the transition metals known as excellent catalysts for asymmetric synthesis has optically active diphosphine ligands as source of chirality; in spite of the great variety of chiral ligands available there is still demand for the development of catalysts which display the requirements of high enantioselectivity, diastereoselectivity and productivity in fine chemicals, fragrances, flavours, agrochemicals. Spurred by these observations we have developed some “mixed” electrondeficient aminophosphonite-phosphite and aminophosphonite-phosphinite. The term “mixed” indicates that the ligands gather one or more stereogenic sp3 carbon atoms of an alpha-aminoalcohol with the (R) or (S) atropisomeric chirality of the 1,1’-binaphthyl moiety. The Rh(I)-complexes derived from these chiral ligands can be valuable catalysts in hydroformylation of Carbapenem antibiotics precursors. Same selected results are summarized in the table.
Settore CHIM/03 - Chimica Generale e Inorganica
Società chimica italilana
Chiral Aminophosphonite-phosphite and Aminophosphonite-phosphinite Ligands in Asymmetric Hydroformylation of Carbapenem Antibiotics Precursors / S.R. Araneo, E. Cesarotti, I. Rimoldi, S. Tassi. ((Intervento presentato al 21. convegno Congresso Nazionale della Società Chimica Italiana tenutosi a Torino nel 2003.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/166309
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