The effects of Salvinorin A, (Salvia divinorum principal ingredient), a potent k-opioid natural hallucinogen, on learning and memory were investigated. Wistar rats were tested in the 8-arm radial maze, for object recognition and passive avoidance tasks for spatial, episodic, and aversive memory. Attention was assessed using a latent inhibition task. Salvinorin A (80-640 mg/kg subcutaneous [sc]) did not affect short-term memory, but it impaired spatial long-term memory. Episodic and aversive memories were impaired by salvinorin A (160-640 mg/kg). Memory impairment was blocked by the selective k-opioid receptor antagonist, nor-binaltorphimine ([nor-B]; 0.5-1 mg/kg, intraperitoneal [ip]). Salvinorin A (160 mg/kg) disrupted latent inhibition, after LiCl treatment, such as reduced sucrose intake, suggesting an attention would result in an impairment of cognitive behavior. These findings demonstrate for the first time that salvinorin A has deleterious effects on learning and memory, through a k-opioid receptor mechanism.

Learning and Memory Impairment Induced by Salvinorin A, the Principal Ingredient of Salvia divinorum, in Wistar rats / D. Braida, A. Donzelli, R. Martucci, V. Capurro, M. Sala. - In: INTERNATIONAL JOURNAL OF TOXICOLOGY. - ISSN 1091-5818. - 30:6(2011 Dec), pp. 650-661.

Learning and Memory Impairment Induced by Salvinorin A, the Principal Ingredient of Salvia divinorum, in Wistar rats

D. Braida
Primo
;
A. Donzelli
Secondo
;
R. Martucci;V. Capurro
Penultimo
;
M. Sala
Ultimo
2011

Abstract

The effects of Salvinorin A, (Salvia divinorum principal ingredient), a potent k-opioid natural hallucinogen, on learning and memory were investigated. Wistar rats were tested in the 8-arm radial maze, for object recognition and passive avoidance tasks for spatial, episodic, and aversive memory. Attention was assessed using a latent inhibition task. Salvinorin A (80-640 mg/kg subcutaneous [sc]) did not affect short-term memory, but it impaired spatial long-term memory. Episodic and aversive memories were impaired by salvinorin A (160-640 mg/kg). Memory impairment was blocked by the selective k-opioid receptor antagonist, nor-binaltorphimine ([nor-B]; 0.5-1 mg/kg, intraperitoneal [ip]). Salvinorin A (160 mg/kg) disrupted latent inhibition, after LiCl treatment, such as reduced sucrose intake, suggesting an attention would result in an impairment of cognitive behavior. These findings demonstrate for the first time that salvinorin A has deleterious effects on learning and memory, through a k-opioid receptor mechanism.
drug abuse; K-opioid receptor; Maze; object recognition; passive avoidance; toxicity
Settore BIO/14 - Farmacologia
29-set-2011
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/165864
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