High-density electroencephalography (hd-EEG) combined with transcranial magnetic stimulation (TMS) provides a direct and non-invasive measure of cortical excitability and connectivity in humans and may be employed to track over time pathological alterations, plastic changes and therapy-induced modifications in cortical circuits. However, the diagnostic/monitoring applications of this technique would be limited to the extent that TMS-evoked potentials are either stereotypical (non-sensitive) or random (non-repeatable) responses. Here, we used controlled changes in the stimulation parameters (site, intensity, and angle of stimulation) and repeated longitudinal measurements (same day and one week apart) to evaluate the sensitivity and repeatability of TMS/hd-EEG potentials.

EEG responses to TMS are sensitive to changes in the perturbation parameters and repeatable over time / S. Casarotto, L.J. Romero Lauro, V. Bellina, A. Girardi Casali, M.C.E. Rosanova, A. Pigorini, S. Defendi, M. Mariotti, M. Massimini. - In: PLOS ONE. - ISSN 1932-6203. - 5:4(2010 Apr), pp. e10281.e10281-1-e10281.e10281-10.

EEG responses to TMS are sensitive to changes in the perturbation parameters and repeatable over time

S. Casarotto;L.J. Romero Lauro;V. Bellina;A. Girardi Casali;M.C.E. Rosanova;A. Pigorini;S. Defendi;M. Mariotti;M. Massimini
2010

Abstract

High-density electroencephalography (hd-EEG) combined with transcranial magnetic stimulation (TMS) provides a direct and non-invasive measure of cortical excitability and connectivity in humans and may be employed to track over time pathological alterations, plastic changes and therapy-induced modifications in cortical circuits. However, the diagnostic/monitoring applications of this technique would be limited to the extent that TMS-evoked potentials are either stereotypical (non-sensitive) or random (non-repeatable) responses. Here, we used controlled changes in the stimulation parameters (site, intensity, and angle of stimulation) and repeated longitudinal measurements (same day and one week apart) to evaluate the sensitivity and repeatability of TMS/hd-EEG potentials.
sensitivity and specificity ; cerebral cortex ; brain mapping ; ROC curve; evoked potentials ; humans ; adult ; electroencephalography ; transcranial magnetic stimulation ; male ; female
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/165333
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