Metformin is a safe drug when correctly used in properly selected patients. However, in real life, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any other major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is quite always surprisingly good.
Metformin and lactic acidosis / S. Vecchio, P. Papa, A. Protti - In: Annual update in intensive care and emergency medicine 2011 / [a cura di] J.L. Vincent. - Berlin [etc.] : Springer, 2011. - ISBN 978-3-642-18080-4. - pp. 685-693 [10.1007/978-3-642-18081-1]
Metformin and lactic acidosis
A. ProttiUltimo
2011
Abstract
Metformin is a safe drug when correctly used in properly selected patients. However, in real life, associated lactic acidosis has been repeatedly, although rarely, reported. The term metformin-induced lactic acidosis refers to cases that cannot be explained by any other major risk factor other than drug accumulation, usually due to renal failure. Treatment consists of vital function support and drug removal, mainly achieved by renal replacement therapy. Despite dramatic clinical presentation, the prognosis of metformin-induced lactic acidosis is quite always surprisingly good.
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