BACKGROUND: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening. CASE PRESENTATION: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract. CONCLUSION: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.
Schwann cell hamartoma: case report / E. Guerini Rocco, F. Iannuzzi, A. Dell'Era, M. Falleni, L. Moneghini, F. Di Nuovo, P. Braidotti, G. Bulfamante, S. Romagnoli. - In: BMC GASTROENTEROLOGY. - ISSN 1471-230X. - 2011:11(2011), p. 68.68.
Schwann cell hamartoma: case report
E. Guerini Rocco;F. IannuzziSecondo
;A. Dell'Era;M. Falleni;P. Braidotti;G. BulfamantePenultimo
;S. RomagnoliUltimo
2011
Abstract
BACKGROUND: Colorectal polyps of mesenchymal origin represent a small percentage of gastrointestinal (GI) lesions. Nevertheless, they are encountered with increasing frequency since the widespread adoption of colonoscopy screening. CASE PRESENTATION: We report a case of a small colonic polyp that presented as intramucosal diffuse spindle cell proliferation with a benign cytological appearance, strong and diffuse immunoreactivity for S-100 protein, and pure Schwann cell phenotype. Careful morphological, immunohistochemical and clinical evaluation emphasize the differences from other stromal colonic lesions and distinguish it from schwannoma, a circumscribed benign nerve sheath tumor that rarely arises in the GI tract. CONCLUSION: As recently proposed, this lesion was finally described as mucosal Schwann cell hamartoma.File | Dimensione | Formato | |
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