The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (P = .04) and in NNRTI resistance after an initial increase (P = .02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.

Transmission of drug-resistant HIV-1 is stabilizing in Europe / J. Vercauteren, A. M. Wensing, D. A. van de Vijver, J. Albert, C. Balotta, O. Hamouda, C. Kücherer, D. Struck, J. C. Schmit, B. Asjö, M. Bruckova, R. J. Camacho, B. Clotet, S. Coughlan, Z. Grossman, A. Horban, K. Korn, L. Kostrikis, C. Nielsen, D. Paraskevis, M. Poljak, E. Puchhammer-Stöck, C. Riva, L. Ruiz, M. Salminen, R. Schuurman, A. Sonnerborg, D. Stanekova, M. Stanojevic, A. M. Vandamme, C. A. Boucher. - In: THE JOURNAL OF INFECTIOUS DISEASES. - ISSN 0022-1899. - 200:10(2009 Nov 15), pp. 1503-1508.

Transmission of drug-resistant HIV-1 is stabilizing in Europe

C. Balotta;C. Riva;
2009

Abstract

The SPREAD Programme investigated prospectively the time trend from September 2002 through December 2005 of transmitted drug resistance (TDR) among 2793 patients in 20 European countries and in Israel with newly diagnosed human immunodeficiency virus type 1 (HIV-1) infection. The overall prevalence of TDR was 8.4% (225 of 2687 patients; 95% confidence interval [CI], 7.4%-9.5%), the prevalence of nucleoside reverse-transcriptase inhibitor (NRTI) resistance was 4.7% (125 of 2687 patients; 95% CI, 3.9%-5.5%), the prevalence of nonucleoside reverse-transcriptase inhibitor (NNRTI) resistance was 2.3% (62 of 2687 patients; 95% CI, 1.8%-2.9%), and the prevalence of protease inhibitor (PI) resistance was 2.9% (79 of 2687 patients; 95% CI, 2.4%-3.6%). There was no time trend in the overall TDR or in NRTI resistance, but there was a statistically significant decrease in PI resistance (P = .04) and in NNRTI resistance after an initial increase (P = .02). We found that TDR appears to be stabilizing in Europe, consistent with recent reports of decreasing drug resistance and improved viral suppression in patients treated for HIV-1 infection.
Settore MED/17 - Malattie Infettive
15-nov-2009
Article (author)
File in questo prodotto:
Non ci sono file associati a questo prodotto.
Pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/165136
Citazioni
  • ???jsp.display-item.citation.pmc??? 100
  • Scopus 221
  • ???jsp.display-item.citation.isi??? 200
social impact