Background: Since when in 1981 a case-control study showed a positive association between coffee and pancreatic cancer, several studies reported inconsistent results on this issue. Materials and methods: We conducted a systematic bibliography search updated March 2011 to identify observational studies providing quantitative estimates for pancreatic cancer risk in relation to coffee consumption. We used a meta-analytic approach to estimate overall relative risk (RR) and 95% confidence interval (CI) for the highest versus the lowest coffee consumption categories, using random-effects models. Results: Based on 37 case-control and 17 cohort studies (10 594 cases), the pooled RR for the highest versus lowest intake was 1.13 (95% CI 0.99-1.29). Considering only the smoking-adjusting studies, the pooled RRs were 1.10 (95% CI 0.92-1.31) for the 22 case-control, 1.04 (95% CI 0.80-1.36) for the 15 cohort, and 1.08 (95% CI 0.94- 1.25) for all studies. The pooled RR for the increment of one cup of coffee per day was 1.03 (95% CI 0.99-1.06) for the 28 smoking-adjusting studies reporting three or more coffee consumption categories. No significant heterogeneity was observed across strata of study design, sex, geographic region, and other selected characteristics. Conclusions: This meta-analysis provides quantitative evidence that coffee consumption is not appreciably related to pancreatic cancer risk, even at high intakes.
A meta-analysis of coffee consumption and pancreatic cancer / F. Turati, C. Galeone, V. Edefonti, M. Ferraroni, P. Lagiou, C. La Vecchia, A. Tavani. - In: ANNALS OF ONCOLOGY. - ISSN 0923-7534. - 23:2(2012 Feb), pp. 311-318.
|Titolo:||A meta-analysis of coffee consumption and pancreatic cancer|
TURATI, FEDERICA (Primo)
GALEONE, CARLOTTA (Secondo)
LA VECCHIA, CARLO VITANTONIO BATTISTA (Penultimo)
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
|Data di pubblicazione:||feb-2012|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/annonc/mdr331|
|Appare nelle tipologie:||01 - Articolo su periodico|