Recently, three novel human polyomaviruses were discovered: KIPyV, WUPyV and MCPyV. To study the genetic variability of these viruses, an evolutionary analysis of the large T antigen, small t antigen, VP1, VP2 and VP3 genes was carried out. Of the genes analyzed, only the small t antigen of KIPyV and MCPyV was found to be under statistically supported selective pressure. In KIPyV, 31 selected sites were found under positive selection (ω(2) = 1.54), with posterior probabilities above 0.75. Of these sites, 17 are located in the J domain and two of these are located in the HPDGG box. Thirteen of these sites were identified as being under positive selection at the 99% confidence level. Moreover, seven codons were under significant purifying selection, particularly in the J domain. In MCPyV, we confirmed the five sites already found to be under positive selection (posterior robabilities 0.99). Selective pressure analysis may provide useful information on viral evolution.
Genetic variability of the small t antigen of the novel KI, WU and MC polyomaviruses / M. Ciccozzi, M. Babakir Mina, A. Lo Presti, F. Farchi, G. Zehender, E. Ebranati, C.F. Perno, M. Ciotti. - In: ARCHIVES OF VIROLOGY. - ISSN 0304-8608. - 155:9(2010 Sep), pp. 1433-1438.
|Titolo:||Genetic variability of the small t antigen of the novel KI, WU and MC polyomaviruses|
|Parole Chiave:||Molecular evolution ; KI WU MC Polyomaviruses|
|Settore Scientifico Disciplinare:||Settore MED/17 - Malattie Infettive|
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/42 - Igiene Generale e Applicata
|Data di pubblicazione:||set-2010|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00705-010-0725-x|
|Appare nelle tipologie:||01 - Articolo su periodico|