MicroRNAs (miRNAs) are a family of regulatory molecules involved in many physiological processes, including activation of cells of the immune system. This study investigated the effect of Escherichia coli lipopolysaccharide (LPS) and Staphylococcus aureus enterotoxin B (SEB) on the expression of five miRNAs involved in the inflammatory response, including miR-9, miR-125b, miR-155, miR-146a and miR-223, in bovine CD14+ cells (monocytes). Incubation of monocytes with EB induced down-regulation of miR-155, miR-223 and miR-125b, but not the anti-inflammatory miRNA miR-146a. Conversely, incubation with LPS upregulated both miR-155 and miR-146a. In vitro incubation of isolated CD14+ bovine monocytes with LPS and SEB elicited different and opposite expression of miRNAs reportedly involved in inflammatory reactions.

Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes / F. Dilda, G. Gioia, L. Pisani, L. Restelli, C. Lecchi, F. Albonico, V. Bronzo, M. Mortarino, F. Ceciliani. - In: THE VETERINARY JOURNAL. - ISSN 1090-0233. - 192:3(2012 Jun), pp. 514-516. [10.1016/j.tvjl.2011.08.018]

Escherichia coli lipopolysaccharides and Staphylococcus aureus enterotoxin B differentially modulate inflammatory microRNAs in bovine monocytes

F. Dilda;G. Gioia;L. Pisani;L. Restelli;C. Lecchi;F. Albonico;V. Bronzo;M. Mortarino;F. Ceciliani
2012

Abstract

MicroRNAs (miRNAs) are a family of regulatory molecules involved in many physiological processes, including activation of cells of the immune system. This study investigated the effect of Escherichia coli lipopolysaccharide (LPS) and Staphylococcus aureus enterotoxin B (SEB) on the expression of five miRNAs involved in the inflammatory response, including miR-9, miR-125b, miR-155, miR-146a and miR-223, in bovine CD14+ cells (monocytes). Incubation of monocytes with EB induced down-regulation of miR-155, miR-223 and miR-125b, but not the anti-inflammatory miRNA miR-146a. Conversely, incubation with LPS upregulated both miR-155 and miR-146a. In vitro incubation of isolated CD14+ bovine monocytes with LPS and SEB elicited different and opposite expression of miRNAs reportedly involved in inflammatory reactions.
MiRNA; monocytes; lipopolysaccharide; Staphylococcus aureus; enterotoxin B; bovine
Settore VET/03 - Patologia Generale e Anatomia Patologica Veterinaria
Settore VET/05 - Malattie Infettive degli Animali Domestici
Settore VET/06 - Parassitologia e Malattie Parassitarie degli Animali
giu-2012
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/164381
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