Two coagulation tests, Recalcified Activated Clotting Time (RACT) and Hemochron, were compared with the activated partial thromboplastin time (APTT) in in vitro heparinization experiments and in patients heparinized for long term extracorporeal circulation (ECC) to determine their suitability as guidelines for heparin administration. All tests had good precision, with a small variability between methods. There was satisfactory correlation with the heparin level in vivo (r = 0.77 for RACT; r = 0.80 for Hemochron and r = 0.82 for APTT) too, while the in vitro r was always greater than or equal to 0.94. Nevertheless, APTT values for plasma heparin levels higher than 1.5 U/ml were markedly prolonged, with a large standard deviation, and often "unclottable". The good correlation between the three tests, makes it possible to substitute RACT and Hemochron for APTT, during long-term ECC

Evaluation of tests for heparin control during long-term extracorporeal circulation / L. D. Uziel, M. Cugno, E. Cacciabue, A. Colombo, R. Stabilini, D. Mascheroni, A. Agostoni. - In: INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS. - ISSN 0391-3988. - 9:2(1986 Mar), pp. 111-116.

Evaluation of tests for heparin control during long-term extracorporeal circulation

L. D. Uziel;M. Cugno;A. Agostoni
1986-03

Abstract

Two coagulation tests, Recalcified Activated Clotting Time (RACT) and Hemochron, were compared with the activated partial thromboplastin time (APTT) in in vitro heparinization experiments and in patients heparinized for long term extracorporeal circulation (ECC) to determine their suitability as guidelines for heparin administration. All tests had good precision, with a small variability between methods. There was satisfactory correlation with the heparin level in vivo (r = 0.77 for RACT; r = 0.80 for Hemochron and r = 0.82 for APTT) too, while the in vitro r was always greater than or equal to 0.94. Nevertheless, APTT values for plasma heparin levels higher than 1.5 U/ml were markedly prolonged, with a large standard deviation, and often "unclottable". The good correlation between the three tests, makes it possible to substitute RACT and Hemochron for APTT, during long-term ECC
Extracorporeal circulation ; analysis of variance ; blood coagulation tests ; humans ; heparin ; partial thromboplastin time
Settore MED/09 - Medicina Interna
INTERNATIONAL JOURNAL OF ARTIFICIAL ORGANS
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/164009
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