Background: Aspergillus terreus causes invasive aspergillosis (IA) in immunocompromised individuals and can be the leading cause of IA in certain medical centers. We examined a large isolate collection (n = 117) for the presence of cryptic A. terreus species and employed a genome scanning method, Inter-Simple Sequence Repeat (ISSR) PCR to determine A. terreus population structure. Results: Comparative sequence analyses of the calmodulin locus revealed the presence of the recently recognized species A. alabamensis (n = 4) in this collection. Maximum parsimony, Neighbor joining, and Bayesian clustering of the ISSR data from the 113 sequence-confirmed A. terreus isolates demonstrated that one clade was composed exclusively of isolates from Europe and another clade was enriched for isolates from the US. Conclusions: This study provides evidence of a population structure linked to geographical origin in A. terreus.
Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering / C.O.S. Neal, A.O. Richardson, S.F. Hurst, A.M.Tortorano, M.A. Viviani, D.A. Stevens, S.A. Balajee. - In: BMC MICROBIOLOGY. - ISSN 1471-2180. - 11(2011), pp. 203.1-203.7.
Global population structure of Aspergillus terreus inferred by ISSR typing reveals geographical subclustering
A.M.Tortorano;
2011
Abstract
Background: Aspergillus terreus causes invasive aspergillosis (IA) in immunocompromised individuals and can be the leading cause of IA in certain medical centers. We examined a large isolate collection (n = 117) for the presence of cryptic A. terreus species and employed a genome scanning method, Inter-Simple Sequence Repeat (ISSR) PCR to determine A. terreus population structure. Results: Comparative sequence analyses of the calmodulin locus revealed the presence of the recently recognized species A. alabamensis (n = 4) in this collection. Maximum parsimony, Neighbor joining, and Bayesian clustering of the ISSR data from the 113 sequence-confirmed A. terreus isolates demonstrated that one clade was composed exclusively of isolates from Europe and another clade was enriched for isolates from the US. Conclusions: This study provides evidence of a population structure linked to geographical origin in A. terreus.File | Dimensione | Formato | |
---|---|---|---|
1471-2180-11-203.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
863.8 kB
Formato
Adobe PDF
|
863.8 kB | Adobe PDF | Visualizza/Apri |
1471-2180-11-203.pdf
accesso aperto
Tipologia:
Pre-print (manoscritto inviato all'editore)
Dimensione
836.63 kB
Formato
Unknown
|
836.63 kB | Unknown | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.