The shape of anodal strength-interval curves and make and break excitation mechanisms are investigated in a 2D anisotropic Bidomain model, with different membrane models and action potential durations, and in a 3D rotational anisotropic Bidomain model, with axisymmetric or orthotropic conductivity properties. The results have shown that the LRd model with a long intrinsic APD exhibits a systolic dip threshold lower than the diastolic threshold, in agreement with previous experimental data. The spatial and temporal analysis of the excitation patterns indicates a novel anode make excitation mechanism with delayed propagation within the transition from break to make mechanisms.

Anode Make and Break Excitation Mechanisms and Strength-Interval Curves: Bidomain Simulations in 3D Rotational Anisotropy / P. Colli-Franzone, L. F. Pavarino, S. Scacchi - In: Functional imaging and modeling of the heart / [a cura di] D. Metaxas, L. Axel. - [s.l] : Springer, 2011. - ISBN 978-3-642-21027-3. - pp. 1-10 (( Intervento presentato al 6. convegno International Conference, FIMH 2011 tenutosi a New York City nel 2011 [10.1007/978-3-642-21028-0_1].

Anode Make and Break Excitation Mechanisms and Strength-Interval Curves: Bidomain Simulations in 3D Rotational Anisotropy

L.F. Pavarino
Secondo
;
S. Scacchi
Ultimo
2011

Abstract

The shape of anodal strength-interval curves and make and break excitation mechanisms are investigated in a 2D anisotropic Bidomain model, with different membrane models and action potential durations, and in a 3D rotational anisotropic Bidomain model, with axisymmetric or orthotropic conductivity properties. The results have shown that the LRd model with a long intrinsic APD exhibits a systolic dip threshold lower than the diastolic threshold, in agreement with previous experimental data. The spatial and temporal analysis of the excitation patterns indicates a novel anode make excitation mechanism with delayed propagation within the transition from break to make mechanisms.
Settore MAT/08 - Analisi Numerica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/163447
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