In this communication we report the study of the reaction between the Schöllkopf reagent and delta2 – isoxazolines bearing different keto groups in position 3. The influence of the R group and the counterion of Schöllkopf reagent on the d.r. and on the yield of the products is evaluated here. Hydrolysis of the adducts provides beta-hydroxy-alpha-aminoacids betasubstituted with a 4,5-dihydroisoxazole, which can undergo further transformations.
Stereoselective Synthesis of beta-Hydroxy-alfa-Amino Acids from Pro-chiral Ketones / G. Cremonesi, P. Dalla Croce, M. Gallanti, C. La Rosa. ((Intervento presentato al 23. convegno International Congress on Heterocyclic Chemistry tenutosi a Glasgow nel 2011.
Stereoselective Synthesis of beta-Hydroxy-alfa-Amino Acids from Pro-chiral Ketones
G. CremonesiPrimo
;P. Dalla CroceSecondo
;M. GallantiPenultimo
;C. La RosaUltimo
2011
Abstract
In this communication we report the study of the reaction between the Schöllkopf reagent and delta2 – isoxazolines bearing different keto groups in position 3. The influence of the R group and the counterion of Schöllkopf reagent on the d.r. and on the yield of the products is evaluated here. Hydrolysis of the adducts provides beta-hydroxy-alpha-aminoacids betasubstituted with a 4,5-dihydroisoxazole, which can undergo further transformations.
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