CONTEXT: Benzene is a ubiquitous pollutant; smoking habit, genetic polymorphisms, and analytical difficulties impact the identification of the best biomarker. OBJECTIVE: To apply a systematic quantitative approach to evaluate urinary benzene (BEN-U) and S-phenylmercapturic acid (SPMA) as biomarkers of low benzene exposures. METHODS: Seventy-one blue collar refinery workers, 97 white collar refinery workers and 108 general population subjects were included. Intrinsic characteristics, sampling and analytical issues were compared. RESULTS: BEN-U and SPMA were detected in 99% and 78% of samples, which correlated with benzene exposure (r = 0.456 and r = 0.636, respectively) and with urinary cotinine (r = 0.630 and r = 0.570, respectively). Intrinsic characteristics were similar for the two biomarkers: specificity (0.64 and 0.69 for BEN-U and SPMA), sensitivity (0.74 and 0.83), as well as intra- and inter-individual variability (150% and >14 for both). CONCLUSION: BEN-U and SPMA show similar intrinsic characteristics; analytical issues in detecting SPMA suggest that BEN-U is more convenient for investigating low exposure levels.

A quantitative approach to evaluate urinary benzene and S-phenylmercapturic acid as biomarkers of low benzene exposure / S. Fustinoni, L. Campo, R. Mercadante, D. Consonni, D. Mielzynska, P.A. Bertazzi. - In: BIOMARKERS. - ISSN 1354-750X. - 16:4(2011 Jun), pp. 334-345.

A quantitative approach to evaluate urinary benzene and S-phenylmercapturic acid as biomarkers of low benzene exposure

S. Fustinoni
Primo
;
L. Campo
Secondo
;
R. Mercadante;P.A. Bertazzi
Ultimo
2011

Abstract

CONTEXT: Benzene is a ubiquitous pollutant; smoking habit, genetic polymorphisms, and analytical difficulties impact the identification of the best biomarker. OBJECTIVE: To apply a systematic quantitative approach to evaluate urinary benzene (BEN-U) and S-phenylmercapturic acid (SPMA) as biomarkers of low benzene exposures. METHODS: Seventy-one blue collar refinery workers, 97 white collar refinery workers and 108 general population subjects were included. Intrinsic characteristics, sampling and analytical issues were compared. RESULTS: BEN-U and SPMA were detected in 99% and 78% of samples, which correlated with benzene exposure (r = 0.456 and r = 0.636, respectively) and with urinary cotinine (r = 0.630 and r = 0.570, respectively). Intrinsic characteristics were similar for the two biomarkers: specificity (0.64 and 0.69 for BEN-U and SPMA), sensitivity (0.74 and 0.83), as well as intra- and inter-individual variability (150% and >14 for both). CONCLUSION: BEN-U and SPMA show similar intrinsic characteristics; analytical issues in detecting SPMA suggest that BEN-U is more convenient for investigating low exposure levels.
Sensitivity and Specificity; Occupational Exposure; Air Pollutants, Occupational; Humans; Methods; Benzene; Environmental Monitoring; Cotinine; Adult; Case-Control Studies; Biological Markers
Settore MED/44 - Medicina del Lavoro
giu-2011
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/162861
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