The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).

The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro / S. Hawser, M. Francolini, K. Islam. - In: JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. - ISSN 0305-7453. - 38:4(1996 Oct), pp. 579-587.

The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro

M. Francolini
Secondo
;
1996

Abstract

The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).
Transformation, Genetic ; Antifungal Agents ; Morphogenesis ; Cell Culture Techniques ; Candida albicans ; Microbial Sensitivity Tests ; Cell Cycle
Settore BIO/14 - Farmacologia
ott-1996
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/162693
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