The effects of antifungal agents, with different mechanisms of action, on the morphogenetic transformation by synchronised yeast-phase Candida albicans cells in vitro and their respective anti-Candida activities are described. MIC data demonstrated that the azoles, amphotericin B and echinocandin were the most active agents against four C. albicans strains. Morphogenetic transformation experiments demonstrated that amphotericin B was significantly better at preventing the transformation, under a variety of test conditions, than the azoles and flucytosine: amphotericin B abolished the transformation at low concentrations while the azoles only prevented the morphogenetic transformation at much higher concentrations (> 100 x MIC).
|Titolo:||The effects of antifungal agents on the morphogenetic transformation by Candida albicans in vitro|
FRANCOLINI, MAURA (Secondo)
|Parole Chiave:||Transformation, Genetic ; Antifungal Agents ; Morphogenesis ; Cell Culture Techniques ; Candida albicans ; Microbial Sensitivity Tests ; Cell Cycle|
|Settore Scientifico Disciplinare:||Settore BIO/14 - Farmacologia|
|Data di pubblicazione:||ott-1996|
|Appare nelle tipologie:||01 - Articolo su periodico|