Come dansyl with me! A small library of naphthyl gluco derivatives was synthesised from methyl α-D-glucopyranoside without protection/ deprotection steps. One library member, dansyl C-glucoside 5, showed an extraordinary anti-inflammatory activity, protecting 100□% of mice from sepsis at a dose of 25 μg□kg-1.

Dansyl C-glucoside as a novel agent against endotoxic shock / B. La Ferla, V. Spinosa, G. D'Orazio, M. Palazzo, A. Balsari, A.A. Foppoli, C. Rumio, F. Nicotra. - In: CHEMMEDCHEM. - ISSN 1860-7179. - 5:10(2010 Oct 04), pp. 1677-1680. [10.1002/cmdc.201000282]

Dansyl C-glucoside as a novel agent against endotoxic shock

M. Palazzo;A. Balsari;A.A. Foppoli;C. Rumio;
2010-10-04

Abstract

Come dansyl with me! A small library of naphthyl gluco derivatives was synthesised from methyl α-D-glucopyranoside without protection/ deprotection steps. One library member, dansyl C-glucoside 5, showed an extraordinary anti-inflammatory activity, protecting 100□% of mice from sepsis at a dose of 25 μg□kg-1.
Settore MED/04 - Patologia Generale
CHEMMEDCHEM
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/162661
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