Several studies have described in autistic patients an overgrowth of unusual gut bacterial strains, able to push the fermentation of tyrosine up to the formation of p-cresol. We compared levels of urinary p-cresol, measured by high-performance liquid chromatography-ultraviolet, in 59 matched case-control pairs. Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age (p < 0.01), typically females (p < 0.05), and more severely affected regardless of sex (p < 0.05). Urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences. Hence, elevated urinary p-cresol may serve as a biomarker of autism liability in small children, especially females and more severely affected males.
|Titolo:||Urinary p-cresol is elevated in small children with severe autism spectrum disorder|
|Parole Chiave:||Regression Analysis; Analysis of Variance; Humans; Child; Child, Preschool; Child Development Disorders, Pervasive; Cotinine; Cresols; Adolescent; Biological Markers; Diagnostic and Statistical Manual of Mental Disorders; Female; Male|
|Settore Scientifico Disciplinare:||Settore MED/39 - Neuropsichiatria Infantile|
|Data di pubblicazione:||mag-2011|
|Digital Object Identifier (DOI):||10.3109/1354750X.2010.548010|
|Appare nelle tipologie:||01 - Articolo su periodico|