[GRAPHICS] The reaction of N,N-dialkylhydrazine/2LiCl adducts with aryl bromides in the presence of Pd-2(dba)(3) as the palladium source, Xantphos or X-phos as the ligands, toluene as the solvent, and NaOBu-t as the base provides an efficient route to N,N-dialkyl-N,-arylhydrazines. Best results were obtained by using N,N-dialkylhydrazine/2LiCl adducts prepared in situ, omitting their isolation.
Synthesis of N,N-dialkyl-N '-arylhydrazines via palladium-catalyzed N-arylation by using N,N-dialkylhydrazines/2LiCl adducts / S. Cacchi, G. Fabrizi, A. Goggiamani, E. Licandro, S. Maiorana, D. Perdicchia. - In: ORGANIC LETTERS. - ISSN 1523-7060. - 7:8(2005), pp. 1497-1500.
Synthesis of N,N-dialkyl-N '-arylhydrazines via palladium-catalyzed N-arylation by using N,N-dialkylhydrazines/2LiCl adducts
E. Licandro;S. MaioranaPenultimo
;D. PerdicchiaUltimo
2005
Abstract
[GRAPHICS] The reaction of N,N-dialkylhydrazine/2LiCl adducts with aryl bromides in the presence of Pd-2(dba)(3) as the palladium source, Xantphos or X-phos as the ligands, toluene as the solvent, and NaOBu-t as the base provides an efficient route to N,N-dialkyl-N,-arylhydrazines. Best results were obtained by using N,N-dialkylhydrazine/2LiCl adducts prepared in situ, omitting their isolation.
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