BACKGROUND: Endometrial cancer is strongly associated with body mass index (BMI), but the influence of BMI history and of different types of obesity is uncertain. METHODS: A case–control study was carried out in Italy including 454 cases and 908 controls admitted to hospital for acute non-hormone-related conditions. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using multivariate logistic and spline regression models. RESULTS: The OR for BMI 430 at diagnosis compared with 20 to o25 kgm 2 was 4.08 (95% CI: 2.90–5.74). The association for BMI was monotonic with a possible steeper increase for BMI above 28. Conversely, waist-to-hip ratio (WHR) showed a bell shaped curve with increased OR (2.10; 95% CI: 1.43–3.09) in the intermediate tertile only. After stratification by BMI at diagnosis, history of weight loss and BMI at age 30 did not influence endometrial cancer risk. History of obesity in middle age had a weak and not significant adverse effect among obese women (OR¼1.60; 95% CI: 0.52–4.96). CONCLUSION: The predominant importance of recent weight compared to lifetime history, justifies encouraging weight reduction in women at any age.
|Titolo:||Anthropometric measures at different ages and endometrial cancer risk|
|Parole Chiave:||Odds ratio ; age factors ; body height ; humans ; aged ; Body Mass Index ; Italy ; body weight ; risk ; endometrial neoplasms ; waist-hip ratio ; logistic models ; adult ; case-control studies ; middle aged ; female|
|Settore Scientifico Disciplinare:||Settore MED/01 - Statistica Medica|
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||29-mar-2011|
|Digital Object Identifier (DOI):||10.1038/bjc.2011.63|
|Appare nelle tipologie:||01 - Articolo su periodico|