Heparanase is an enzyme that is over-expressed in spme pathological conditions such as tumor growth, metastasis and heavy inflammation forms.Therefore the development of inhibitors of HSase activity is an important target for designing antiangiogenic and antimetastatic agents. In this work there were studied and tested three different oligosaccharides using a method based on direct quantification of residual substrate by mass spectroscopy (ESI.IT) coupled with chromatographic separation (HPLC).
SYNTHETIC GLYCOSAMINOGLYCAN PENTASACCHARIDES FOR INHIBITION OF ENZIMATIC ACTIVITY OF HEPARANASE / M. Ferro, L. Lay, A. Bisio, M. Guerrini, A. Naggi. ((Intervento presentato al 12. convegno Convegno-Scuola sulla Chimica dei Carboidrati tenutosi a Pontignano (Siena) nel 2010.
SYNTHETIC GLYCOSAMINOGLYCAN PENTASACCHARIDES FOR INHIBITION OF ENZIMATIC ACTIVITY OF HEPARANASE
M. FerroPrimo
;L. LaySecondo
;
2010
Abstract
Heparanase is an enzyme that is over-expressed in spme pathological conditions such as tumor growth, metastasis and heavy inflammation forms.Therefore the development of inhibitors of HSase activity is an important target for designing antiangiogenic and antimetastatic agents. In this work there were studied and tested three different oligosaccharides using a method based on direct quantification of residual substrate by mass spectroscopy (ESI.IT) coupled with chromatographic separation (HPLC).
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