An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB

Cardiopulmonary bypass increases plasma bradykinin concentrations / M. Cugno, J. Nussberger, P. Biglioli, M. G. Giovagnoni, M. Gardinali, A. Agostoni. - In: IMMUNOPHARMACOLOGY. - ISSN 0162-3109. - 43:2-3(1999 Sep), pp. 145-147. [10.1016/S0162-3109(99)00072-7]

Cardiopulmonary bypass increases plasma bradykinin concentrations

M. Cugno
Primo
;
P. Biglioli;A. Agostoni
Ultimo
1999

Abstract

An increase of bradykinin (BK) plasma levels together with the activation coagulation cascade, fibrinolysis, complement and cytokines was observed during cardiopulmonary bypass (CPB). Since the procedure of extracorporeal circulation completely excludes the lung, the major site of BK catabolism, our data suggest that a reduced catabolism could contribute to the increase of BK during CPB
Bradykinin; Cardiopulmonary bypass; Catabolism
Settore MED/09 - Medicina Interna
Settore MED/23 - Chirurgia Cardiaca
set-1999
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/162073
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